List of Ongoing & Completed Projects

Improving the accuracy of sleep detection from ambulatory wearables

This project is made available by a generous gift from a company. The fund will help the PI pursue a prior unfunded research direction to improve the accuracy of sleep detection from ambulatory wearables.

Li Lab start-up fund

This start-up package is established for the PI to successfully initiate his independent research program at MGH. The funding serves to facilitate the expeditious start-up of the research lab, including the support of reasonable expenses such as effort and the PI and other personnel as well as materials and supplies.

Circadian rest-activity rhythms and links with cognitive function in women aging with HIV

The BRI Fund to Sustain Research Excellence (FSRE) will provide support to allow the team to prepare more compelling preliminary results to boost the success of a resubmission of an R01 application that will evaluate circadian rest-activity rhythms (CRAR), the influence of menopause on CRAR, and the association of CRAR with cognition in women living with HIV (WLH) and HIV seronegative women.

Daytime napping and Alzheimer’s disease in middle-to-older aged adults: Timing, irregularity, and interaction with genetic risks

This project will test whether actigraphy-measured napping is cross-sectionally associated with cognition and prospectively associated with incident dementia/AD in a sample of ~99,000 middle- to older-aged participants.

Timing and irregularity of daytime napping and Alzheimer’s disease

The proposed study will address two aims: (1) To investigate the relationship of timing and irregularity of daytime naps with longitudinal cognitive decline, and AD; and (2) To determine whether timing and irregularity of daytime naps interact with genetic risks of AD to influence the trajectory of cognitive change and incident Alzheimer’s dementia

Association between rest activity circadian rhythm and cognition in PLWH

The goal of this project is to characterize the circadian patterns in PLWH using a novel data adaptive tool for analyzing rest activity data, examine the association between circadian variations and cognition in PLWH, and explore the potential mechanisms.

Circadian disturbances and cognitive impairment in people living with HIV

The goal of this project is to determine the role of circadian regulation in HIV-associated cognitive impairment.

Circadian regulation, autonomic function, and Alzheimer’s disease

The goal of this project is to determine the roles of circadian dysregulation and autonomic dysfunction in the development/progression of AD utilizing novel circadian and autonomic measures derived from nonlinear analyses.

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